Cell Danger Response, Healing Cycle & Chronic Disease | Dr Robert Naviaux
with Dr Robert Naviaux, Professor of Medicine, Pediatrics, and Pathology
Overview
Why do some people recover from illness while others develop persistent, chronic health conditions?
In this video, Dr Robert Naviaux explores the Cell Danger Response, the healing cycle, and their relationship to chronic disease. He explains how chronic illness may arise when the body’s normal healing process becomes blocked or incomplete, leaving cells in a persistent state of stress or defense. The session examines the role of mitochondria, metabolism, purinergic signalling, extracellular ATP, and cellular communication in recovery and disease progression. Dr Naviaux also discusses how systems biology and metabolomics can help identify patterns in chronic conditions, offering a deeper understanding of how the body moves from injury toward healing.
Objectives
- Understand the Cell Danger Response and how it functions as a universal response to injury, stress, infection, toxins, and other triggers.
- Explore how the healing cycle supports recovery through coordinated changes in metabolism, mitochondria, immune activity, and cellular signalling.
- Differentiate between acute illness and chronic illness through the concept of blocked or incomplete healing.
- Recognise the role of mitochondria and extracellular ATP in regulating the stages of the Cell Danger Response.
- Learn how systems biology and metabolomics can provide insight into chronic disease patterns and potential pathways for recovery.
Bio - Dr Robert Naviaux,
Professor of Medicine, Pediatrics and Pathology
Dr. Naviaux is a Professor of Genetics, in the Departments of Medicine, Pediatrics, and Pathology. He directs a core laboratory for metabolomics at UCSD. He is the co-founder and a former president of the Mitochondrial Medicine Society (MMS), and a founding associate editor of the journal Mitochondrion. He is an internationally known expert in human genetics, inborn errors of metabolism, metabolomics, and mitochondrial medicine. He is the discoverer of the cause of Alpers syndrome—the oldest Mendelian form of mitochondrial disease—and the developer of the first DNA test to diagnose it. Dr. Naviaux’s lab has developed a number of advanced technologies like biocavity laser spectroscopy and mtDNA mutation detection by mass spectrometry.
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